Kolosnjaj Jelena, Szwarc Henri, Moussa Fathi
UMR CNRS 8612, Faculté de Pharmacie, Université Paris-Sud 11, Châtenay-Malabry, France.
Adv Exp Med Biol. 2007;620:181-204. doi: 10.1007/978-0-387-76713-0_14.
As for fullerenes, the potential and the growing use of CNT and their mass production have raised several questions about their safety and environmental impact. Research on the toxicity of carbon nanotubes has just begun and the data are still fragmentary and subject to criticisms. Preliminary results highlight the difficulties in evaluating the toxicity of this new and heterogeneous carbon nanoparticle family. A number of parameters including structure, size distribution and surface area, surface chemistry and surface charge, and agglomeration state as well as purity of the samples, have considerable impact on the reactivity of carbon nanotubes. However, available data clearly show that, under some conditions, nanotubes can cross the membrane barriers and suggests that if raw materials reach the organs they can induce harmful effects as inflammatory and fibrotic reactions. Therefore, many further studies on well-characterized materials are necessary to determine the safety of carbon nanotubes as well as their environmental impact.
至于富勒烯，碳纳米管的潜力、日益广泛的应用及其大规模生产引发了一些关于其安全性和环境影响的问题。对碳纳米管毒性的研究刚刚起步，数据仍然零散且饱受批评。初步结果凸显了评估这一新型且异质的碳纳米颗粒家族毒性的困难。包括结构、尺寸分布和表面积、表面化学和表面电荷、团聚状态以及样品纯度在内的许多参数，对碳纳米管的反应性都有相当大的影响。然而，现有数据清楚地表明，在某些条件下，纳米管能够穿过膜屏障，并表明如果原材料进入器官，它们可能引发诸如炎症和纤维化反应等有害影响。因此，有必要对特性明确的材料进行更多进一步研究，以确定碳纳米管的安全性及其对环境的影响。
