Uszyński W, Uszyński M, Zekanowska E
Regional Hospital in Włocławek, Poland.
Adv Med Sci. 2007;52:262-4.
Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour.
The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 healthy, age-matched women at term). Blood samples were collected in the 1st, 2nd and 3rd stages of labour as well as two hours after placenta expulsion. The levels of soluble E- and P-selectins were measured by immunoenzymatic method (ELISA).
The levels of soluble E- and P-selectins in blood plasma of labouring women were within the similar medians and ranges during the 1st, 2nd and 3rd stages of labour as well as two hours after labour (p > 0.05).
The natural labour does not influence the level of soluble E-selectin and soluble P-selectin in blood plasma of labouring women, therefore the prognostic values of these markers of preeclampsia are preserved in the time of labour.
我们的问题是子痫前期的两种生化标志物E选择素和P选择素在分娩的特定阶段是否仍保持其预后价值，还是在分娩过程中失去该价值。
研究组由36名顺产的健康产妇组成（对照组为15名足月的、年龄匹配的健康女性）。在分娩的第一、第二和第三阶段以及胎盘娩出后两小时采集血样。采用免疫酶法（ELISA）测定可溶性E选择素和P选择素的水平。
在分娩的第一、第二和第三阶段以及分娩后两小时，产妇血浆中可溶性E选择素和P选择素的水平处于相似的中位数和范围内（p>0.05）。
自然分娩不影响产妇血浆中可溶性E选择素和可溶性P选择素的水平，因此子痫前期这些标志物的预后价值在分娩时得以保留。
