Johnson Paul D R, Azuolas Joseph, Lavender Caroline J, Wishart Elwyn, Stinear Timothy P, Hayman John A, Brown Lynne, Jenkin Grant A, Fyfe Janet A M
Infectious Disease Department, Austin Health, Melbourne, Victoria, Australia.
Emerg Infect Dis. 2007 Nov;13(11):1653-60. doi: 10.3201/eid1311.061369.
Buruli ulcer (BU) occurs in >30 countries. The causative organism, Mycobacterium ulcerans, is acquired from the environment, but the exact mode of transmission is unknown. We investigated an outbreak of BU in a small coastal town in southeastern Australia and screened by PCR mosquitoes caught there. All cases of BU were confirmed by culture or PCR. Mosquitoes were trapped in multiple locations during a 26-month period. BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007. We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus). Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets.
布氏溃疡（BU）在30多个国家均有发生。其病原体溃疡分枝杆菌源于环境，但确切传播方式尚不清楚。我们对澳大利亚东南部一个沿海小镇发生的布氏溃疡疫情进行了调查，并对在当地捕获的蚊子进行了聚合酶链反应（PCR）筛查。所有布氏溃疡病例均通过培养或PCR确诊。在26个月的时间里，在多个地点捕获了蚊子。2001年1月至2007年4月期间，朗斯代尔角/昆斯克利夫的48名居民和31名游客患上了布氏溃疡。我们检测了在朗斯代尔角捕获的11504只蚊子（主要是尖音库蚊）。48个样本池（5个物种）的插入序列IS2404呈阳性（最大似然估计为4.3/1000），通过检测另外3个PCR靶点，我们在一部分样本池中证实了溃疡分枝杆菌的存在。
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