Yu Binbing
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Gateway Building, Suite 3C309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.
Biom J. 2008 Jun;50(3):386-94. doi: 10.1002/bimj.200710399.
Mixture cure models have been utilized to analyze survival data with possible cure. This paper considers the inclusion of frailty into the mixture cure model to model recurrent event data with a cure fraction. An attractive feature of the proposed model is the allowance for heterogeneity in risk among those individuals experiencing the event of interest in addition to the incorporation of a cured component. Maximum likelihood estimates can be obtained using the Expectation Maximization algorithm and standard errors are calculated from the Bootstrap method. The model is applied to hospital readmission data among colorectal cancer patients.
混合治愈模型已被用于分析可能存在治愈情况的生存数据。本文考虑将脆弱性纳入混合治愈模型,以对具有治愈比例的复发事件数据进行建模。所提出模型的一个吸引人的特点是,除了纳入治愈成分外,还允许在经历感兴趣事件的个体之间存在风险异质性。可以使用期望最大化算法获得最大似然估计,并通过自助法计算标准误差。该模型应用于结直肠癌患者的医院再入院数据。