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老年人的脂质异常与心血管风险

Lipid abnormalities and cardiovascular risk in the elderly.

作者信息

Milionis Haralampos J, Elisaf Moses S, Mikhailidis Dimitri P

出版信息

Curr Med Res Opin. 2008 Mar;24(3):653-7. doi: 10.1185/030079908X273363. Epub 2008 Jan 23.

Abstract

The relationship between dyslipidaemia and cardiovascular disease is well documented. However, it is relevant to consider that cholesterol levels vary with age. Moreover, there is some controversy regarding the ability of lipid levels to predict vascular risk beyond the age of 70 years. In general, raised low-density lipoprotein cholesterol (LDL-C) and triglyceride levels as well as reduced levels of high-density lipoprotein cholesterol (HDL-C) predict risk in the elderly. There is evidence supporting the use of statins in the elderly. It is also likely that these drugs are under-used in this population.

摘要

血脂异常与心血管疾病之间的关系已有充分记录。然而,需要考虑的是胆固醇水平会随年龄变化。此外,关于70岁以上人群血脂水平预测血管风险的能力存在一些争议。一般来说,低密度脂蛋白胆固醇(LDL-C)和甘油三酯水平升高以及高密度脂蛋白胆固醇(HDL-C)水平降低可预测老年人的风险。有证据支持在老年人中使用他汀类药物。而且这类药物在该人群中可能未得到充分使用。

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