Department of Cardiology, Koç University Hospital, İstanbul, Turkey
Department of Cardiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Turk J Med Sci. 2021 Apr 30;51(2):727-734. doi: 10.3906/sag-2008-165.
BACKGROUND/AIM: Arterial stiffness, known as a predictor of early vascular aging, was defined as the main determinant of cardiovascular mortality and morbidity. However, the relationship between lipid profile and increased arterial stiffness is not clear. The aim of this study is to investigate the relationship between lipid profiles and increased arterial stiffness in patients with early vascular aging syndrome.
A total of 1582 participants —504 (31.8%) of were male and the mean age was 52.8 ±14.2 years— were included in the study . Patients who applied to the hospital for various reasons and who had undergone 24-h blood pressure Holter monitoring were included in this study. Patients were divided into four groups according to pulse wave velocity (PWV) quartiles (Q1 (<6.3), Q2 (6.3–7.4), Q3 (7.5–8.8), Q4 (>8.8)).
We found that in the highest PWV group, patients had higher systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, blood urea nitrogen (BUN), creatinine, urinary albumin excretion (UAE), uric acid(UA), total cholesterol (TC), low-density lipoprotein ( LDL-C), triglycerid (TG), and non- high-density lipoprotein (HDL-C ) levels. Additionally, diabetes mellitus (dm), age, non-HDL-C, and TG/ HDL-C levels were detected as independent risk factors of increased PWV in ordinal logistic regression analysis.
Our study demonstrates that lipid parameters are strongly correlated with increased PWVvalue and early vascular aging. In daily clinical practice, TG\HDL-C ratio, known as atherogenic index, might be used routinely for predicted of early vascular aging and subclinical atherosclerosis.
背景/目的：动脉僵硬度，作为早期血管老化的预测指标，被定义为心血管死亡率和发病率的主要决定因素。然而，脂质谱与动脉僵硬度增加之间的关系尚不清楚。本研究旨在探讨早期血管老化综合征患者的脂质谱与动脉僵硬度增加之间的关系。
共纳入 1582 名参与者——其中 504 名（31.8%）为男性，平均年龄为 52.8±14.2 岁——他们均接受过 24 小时血压动态监测。本研究纳入了因各种原因到医院就诊并接受过 24 小时血压动态监测的患者。根据脉搏波速度（PWV）四分位数（Q1（<6.3）、Q2（6.3-7.4）、Q3（7.5-8.8）、Q4（>8.8））将患者分为四组。
我们发现，在最高 PWV 组中，患者的收缩压（SBP）、舒张压（DBP）、血糖、血尿素氮（BUN）、肌酐、尿白蛋白排泄率（UAE）、尿酸（UA）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）和非高密度脂蛋白胆固醇（非 HDL-C）水平更高。此外，在有序逻辑回归分析中，糖尿病（dm）、年龄、非 HDL-C 和 TG/HDL-C 水平被检测为 PWV 增加的独立危险因素。
我们的研究表明，脂质参数与 PWV 值升高和早期血管老化密切相关。在日常临床实践中，作为致动脉粥样硬化指数的 TG/HDL-C 比值可能被常规用于预测早期血管老化和亚临床动脉粥样硬化。
