[The impact of acute hyperglycemia on the prognosis of ST-segment elevation myocardial infarction].

OBJECTIVE

This study was undertaken to assess the effect of acute hyperglycemia on the in-hospital outcomes in patients with ST-segment elevation myocardial infarction (STEMI).

METHODS

Between January 2006 and July 2006, 356 patients, from 17 hospitals in Beijing were admitted to the hospitals within 24 hours after the onset of STEMI. They were divided into two groups according to the admission glucose level (cutoff value, 11 mmol/L). The in-hospital mortality and cardiovascular events were compared between the two groups. The in-hospital cardiovascular events were defined as in-hospital reinfarction, new-onset heart failure, malignant arrhythmia and stroke.

RESULTS

There were 81 (22.8%) patients with acute hyperglycemia. The in-hospital mortality rate was significantly higher in patients with acute hyperglycemia than in patients without (13.6% VS 5.1%, P = 0.009). The rate of cardiovascular events was also higher in patients with acute hyperglycemia (32.1% VS 20.4%, P = 0.027). By univariate and multivariate logistic regression analysis, high blood glucose on admission (OR, 1.615; 95% CI, 1.116 - 2.338, P = 0.011) was an independent risk factor for in-hospital outcomes.

CONCLUSION

The rate of in-hospital mortality and cardiovascular events was significantly higher in STEMI patients with acute hyperglycemia than in patients without. high blood glucose on admission was an independent risk factor for in-hospital outcomes in patients with STEMI.