Zhao Wei, Hu Da-yi
Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730 China.
Zhonghua Nei Ke Za Zhi. 2007 Oct;46(10):820-3.
This study was undertaken to assess the effect of acute hyperglycemia on the in-hospital outcomes in patients with ST-segment elevation myocardial infarction (STEMI).
Between January 2006 and July 2006, 356 patients, from 17 hospitals in Beijing were admitted to the hospitals within 24 hours after the onset of STEMI. They were divided into two groups according to the admission glucose level (cutoff value, 11 mmol/L). The in-hospital mortality and cardiovascular events were compared between the two groups. The in-hospital cardiovascular events were defined as in-hospital reinfarction, new-onset heart failure, malignant arrhythmia and stroke.
There were 81 (22.8%) patients with acute hyperglycemia. The in-hospital mortality rate was significantly higher in patients with acute hyperglycemia than in patients without (13.6% VS 5.1%, P = 0.009). The rate of cardiovascular events was also higher in patients with acute hyperglycemia (32.1% VS 20.4%, P = 0.027). By univariate and multivariate logistic regression analysis, high blood glucose on admission (OR, 1.615; 95% CI, 1.116 - 2.338, P = 0.011) was an independent risk factor for in-hospital outcomes.
The rate of in-hospital mortality and cardiovascular events was significantly higher in STEMI patients with acute hyperglycemia than in patients without. high blood glucose on admission was an independent risk factor for in-hospital outcomes in patients with STEMI.
本研究旨在评估急性高血糖对ST段抬高型心肌梗死（STEMI）患者院内结局的影响。
2006年1月至2006年7月，来自北京17家医院的356例患者在STEMI发病后24小时内入院。根据入院血糖水平（临界值为11 mmol/L）将他们分为两组。比较两组的院内死亡率和心血管事件。院内心血管事件定义为院内再梗死、新发心力衰竭、恶性心律失常和中风。
有81例（22.8%）急性高血糖患者。急性高血糖患者的院内死亡率显著高于非急性高血糖患者（13.6%对5.1%，P = 0.009）。急性高血糖患者的心血管事件发生率也更高（32.1%对20.4%，P = 0.027）。通过单因素和多因素逻辑回归分析，入院时高血糖（OR，1.615；95%CI，1.116 - 2.338，P = 0.011）是院内结局的独立危险因素。
急性高血糖的STEMI患者的院内死亡率和心血管事件发生率显著高于非急性高血糖患者。入院时高血糖是STEMI患者院内结局的独立危险因素。
