Yamanishi T, Kobayashi C, Tsujimoto I, Koizumi H, Miya S, Yokota Y, Okamoto R, Iida S, Aikawa T, Kohara H, Nishio J, Kogo M
First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, Japan.
J Dent Res. 2008 Feb;87(2):164-8. doi: 10.1177/154405910808700212.
The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio-posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p < 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.
犁骨在颌骨生长中起关键作用这一发现表明,单侧唇腭裂(UCLP)的双侧腭裂结构(其中犁骨与非腭裂侧的继发硬腭分离)会对腭部发育产生负面影响,对此假设进行了验证。对60例完全性UCLP患者进行了形态学分析,包括犁骨与继发硬腭分离的患者(n = 30,b-UCLP)和犁骨与继发硬腭相连的患者(n = 30,u-UCLP),使用了在10天、3个月和12个月龄时获取的石膏模型。b-UCLP患者12个月龄时的腭前后长度显著短于u-UCLP患者,短8.7%(p < 0.05)。此外,b-UCLP患者第一年的腭宽度发育也明显滞后。这些结果表明,UCLP中不常见 的双侧腭裂亚型应纳入腭裂分类。