Huang KuangTzu, Ueda Eric, Chen YenHao, Walker Ameae M
Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA.
J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):69-79. doi: 10.1007/s10911-008-9072-x. Epub 2008 Jan 25.
Since the discovery of physiologically-regulated prolactin (PRL) phosphorylation, one focus of the laboratory has been an examination of the different functions of the unmodified and phosphorylated hormone. In the mammary gland, unmodified PRL promotes growth activities, whereas phosphorylated or pseudophosphorylated PRL antagonizes this while also being a superior agonist for changes that favor differentiation. Phosphorylated PRL also increases expression of the short forms of the PRL receptor. These short forms of the receptor have functions beyond the accepted dominant negative and in mammary epithelial cells are capable of generating an intracellular signal leading to increased tight junction formation and beta-casein expression.
自从发现催乳素（PRL）的生理调节磷酸化以来，该实验室的一个重点一直是研究未修饰和磷酸化激素的不同功能。在乳腺中，未修饰的PRL促进生长活动，而磷酸化或假磷酸化的PRL则对此起拮抗作用，同时也是促进分化变化的更有效的激动剂。磷酸化的PRL还会增加PRL受体短形式的表达。这些受体短形式的功能超出了公认的显性负性功能，在乳腺上皮细胞中能够产生细胞内信号，导致紧密连接形成增加和β-酪蛋白表达增加。
