beta-Actin-derived peptides isolated from acidic extract of rat spleen suppress tumor cell growth.

作者信息

Blishchenko Elena Y, Sazonova Olga V, Yatskin Oleg N, Kalinina Olga A, Tolmazova Anna G, Philippova Marina M, Karelin Andrei A, Ivanov Vadim T

机构信息

Shemyakin-Ovchinnikov Institute of Bio-organic Chemistry, Russian Academy of Sciences, Moscow, V-437, GSP, Russia.

出版信息

J Pept Sci. 2008 Jul;14(7):811-8. doi: 10.1002/psc.1008.

Twenty-two fragments of beta-actin and beta-actin-related protein were isolated from the acidic extracts of rat spleen tissue. beta-Actin fragments (75-90), (78-89), and (78-88), 0.01-1 microM, decreased live cell number of L929 murine tumor fibroblasts by 80-90%, with maximal cytotoxic effect of 30-40%. The fragments of (78-90) segment and the fragment of beta-actin-related protein (69-77) were less active (inhibitory effect up to 55%, cytotoxic-up to 25%).