Tajima Yusuke, Ishibashi Keiichiro, Gonda Tsuyoshi, Miyazaki Tatsuya, Nakada Hiroshi, Takahashi Tateo, Ishida Hideyuki
Dept of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
Gan To Kagaku Ryoho. 2007 Nov;34(12):2050-2.
We report a case of squamous cell carcinoma of the anal canal which showed complete response following chemoradiotherapy. A 54-year-old woman was diagnosed as having squamous cell carcinoma of the anal canal (T2N0M0 stage II). Chemoradiotherapy comprising peroral tegafur/uracil and external radiotherapy (60 Gy) to the pelvic space resulted in complete response 4 months after the initiation of the treatment. PET-CT showed recurrence in paraortic lymph node, right sacral and left pubic bone 11 months after the initiation of treatment, although the primary lesion did not relapse. The patient is now given 5-fluorouracil/cisplatin in addition to external radiotherapy (57.5 Gy) to the metastatic lymph node. This case suggests that we should take measures to prevent distant metastases in the treatment of squamous cell carcinoma of the anal canal.
我们报告一例肛管鳞状细胞癌患者,该患者在放化疗后显示出完全缓解。一名54岁女性被诊断为肛管鳞状细胞癌(T2N0M0,II期)。采用口服替加氟/尿嘧啶联合盆腔外放射治疗(60 Gy),治疗开始4个月后获得完全缓解。治疗开始11个月后,正电子发射断层扫描-计算机断层扫描(PET-CT)显示主动脉旁淋巴结、右骶骨和左耻骨出现复发,尽管原发灶未复发。目前该患者除了对转移淋巴结进行外放射治疗(57.5 Gy)外,还接受氟尿嘧啶/顺铂治疗。该病例提示,在肛管鳞状细胞癌的治疗中,我们应采取措施预防远处转移。