Handa Rio, Iijima Shouhei, Doi Takashi, Oshima Kazuteru, Hoshi Minako, Makari Yoichi, Miyake Yasuhiro, Oshima Satoshi, Kato Takeshi, Kurokawa Eiji, Kikkawa Nobuteru
Dept. of Surgery, Minoh City Hospital Gastrointestinal Research Center.
Gan To Kagaku Ryoho. 2007 Nov;34(12):2108-10.
We report three successful cases with irinotecan (CPT-11 60 mg/m2) + cisplatin (CDDP 30mg/m2) chemotherapy (once in 2 weeks) where S-1 failed to respond to recurrent gastric cancer. Case 1: A total gastrectomy and splenectomy were performed for a cardiac gastric cancer (T3, N2, H0, P0, CY0, por 1, Stage IIIB). An abdominal CT revealed paraortic lymph node metastases 4 months after the surgery. No reductions were noted after S-1 monotherapy. We next treated this patient with CPT-11 + CDDP. An abdominal CT revealed a CRin after 11 courses. Case 2: A total gastrectomy, splenectomy and cholecystectomy were performed for a cardiac gastric cancer (T3, N3, H0, P0, CY1, tub1, Stage IV). After the surgery, we treated this patient with S-1 mono-therapy. However, we finished this treatment for abdominal recurrence. We next treated this patient with CPT-11 + CDDP. An abdominal CT revealed a CR after 24 courses. Case 3: A distal gastrectomy and cholecystectomy were performed for a pyloric gastric cancer (T2, N1, H0, P0, CY0, tub 2, Stage II). An abdominal CT revealed paraortic lymph node metastases 10 months after the surgery. We treated this patient with S-1 + paclitaxel (PTX) chemotherapy. No reductions were noted after 2 courses. We next treated this patient with CPT-11 + CDDP. An abdominal CT revealed a CR after 8 courses.
我们报告了3例使用伊立替康（CPT-11 60mg/m²）+顺铂（CDDP 30mg/m²）化疗（每2周1次）成功治疗的病例，这些病例中S-1对复发性胃癌治疗无效。病例1：因贲门胃癌（T3，N2，H0，P0，CY0，病理类型1，ⅢB期）行全胃切除术和脾切除术。术后4个月腹部CT显示腹主动脉旁淋巴结转移。S-1单药治疗后未见肿瘤缩小。接下来我们用CPT-11 + CDDP治疗该患者。腹部CT显示11个疗程后达到完全缓解（CR）。病例2：因贲门胃癌（T3，N3，H0，P0，CY1，管状腺癌1级，Ⅳ期）行全胃切除术、脾切除术和胆囊切除术。术后我们用S-1单药治疗该患者。然而，因腹部复发停止了该治疗。接下来我们用CPT-11 + CDDP治疗该患者。腹部CT显示24个疗程后达到CR。病例3：因幽门胃癌（T2，N1，H0，P0，CY0，管状腺癌2级，Ⅱ期）行远端胃切除术和胆囊切除术。术后10个月腹部CT显示腹主动脉旁淋巴结转移。我们用S-1 + 紫杉醇（PTX）化疗治疗该患者。2个疗程后未见肿瘤缩小。接下来我们用CPT-11 + CDDP治疗该患者。腹部CT显示8个疗程后达到CR。
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