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[记忆与记忆障碍]

[Memory and memory disorders].

作者信息

Chiu Ming-Jang

机构信息

Department of Neurology, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan.

出版信息

Acta Neurol Taiwan. 2007 Dec;16(4):242-50.

Abstract

Memory is a reconstructive process classified as explicit and implicit memory by level of awareness. Explicit memory is a conscious recollection of either episodic or semantic memory. Episodic memory is from personal experience and is context-specific while semantic memory refers to general knowledge. Implicit memory is from priming, procedure memory or skills. On-line message held by the brain is the working memory. Prospective memory is about something to be done in the future. Over-reliance on gist memory brings in false memory. The stirring of emotion has effect on encoding and consolidation. Explicit memory depends on medial temporal and prefrontal lobes. Priming impinges directly on cerebral cortex. Procedure memory or motor skills are closely related to basal ganglia. Cerebellum plays an important role in classical conditioning and complex motor learning. Age effect on memory is mainly from decreased speed and capacity of the central executive function. Age-associated memory impairment could be normal aging while mild cognitive impairment could be preclinical dementia. Alzheimer's disease starts with episodic memory, frontotemporal dementia defects semantic memory and Lewy's body dementia impairs working memory.

摘要

记忆是一个重构过程,根据意识水平可分为外显记忆和内隐记忆。外显记忆是对情景记忆或语义记忆的有意识回忆。情景记忆来自个人经历,具有情境特异性,而语义记忆则指一般知识。内隐记忆来自启动效应、程序记忆或技能。大脑中保存的在线信息是工作记忆。前瞻性记忆是关于未来要做的事情。过度依赖要点记忆会产生错误记忆。情绪的激发会对编码和巩固产生影响。外显记忆依赖于内侧颞叶和前额叶。启动效应直接作用于大脑皮层。程序记忆或运动技能与基底神经节密切相关。小脑在经典条件反射和复杂运动学习中起重要作用。年龄对记忆的影响主要源于中央执行功能的速度和能力下降。年龄相关的记忆损害可能是正常衰老,而轻度认知障碍可能是临床前痴呆。阿尔茨海默病始于情景记忆,额颞叶痴呆损害语义记忆,路易体痴呆损害工作记忆。

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