Bosques Padilla F J, Barragán Villarreal R F
Departamento de Medicina Interna, Hospital Universitario Dr. José E. González, Monterrey.
Rev Gastroenterol Mex. 1991 Jul-Sep;56(3):145-50.
In the western world, gallstones are constituted completely by or have more than 70% of cholesterol. This is a consequence of a metabolic derangement in the biliary lipids composition. With the administration of quenodesoxicholic and ursodesoxicholic acids, the molar relationship between the biliary lipids modified in order to dissolve the gallstones. With the use of the bile acids alone or in combination we accomplished the complete dissolution in 38-55% of selected patients. In the present paper we review the rationale, indications, posology and monitorization of the patients submitted to treatment with orally bile acids.
在西方世界,胆结石完全由胆固醇构成或胆固醇含量超过70%。这是胆汁脂质成分代谢紊乱的结果。使用鹅去氧胆酸和熊去氧胆酸后,胆汁脂质之间的摩尔关系发生改变,从而使胆结石溶解。单独使用或联合使用胆汁酸,我们使38%至55%的选定患者实现了完全溶解。在本文中,我们回顾了接受口服胆汁酸治疗的患者的治疗原理、适应症、剂量和监测情况。