Chaudhary Anurag, Pandeya S N, Kumar P, Sharma P P, Gupta S, Soni N, Verma K K, Bhardwaj G
Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, U.P., India.
Mini Rev Med Chem. 2007 Dec;7(12):1186-205. doi: 10.2174/138955707782795647.
Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.
康普瑞他汀A-4（CA-4）是最有效的天然来源抗有丝分裂和抗血管生成药物之一。它在多种临床前肿瘤模型中显示出强大的抗肿瘤作用。迄今为止，已经合成了各种CA-4类似物并对其抗癌活性进行了评估。这篇综述旨在汇编各种合成的CA-4类似物的药物化学。
