四跨膜蛋白——调节血小板功能的结构和信号支架
Tetraspanins-structural and signalling scaffolds that regulate platelet function.
作者信息
Goschnick Matt W, Jackson Denise E
机构信息
Immunoreceptor Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg, Victoria 3084, Australia.
出版信息
Mini Rev Med Chem. 2007 Dec;7(12):1248-54. doi: 10.2174/138955707782795656.
PMID:18220977
Abstract
There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the 'outside-in' signalling properties of the major platelet integrin, integrin alpha(IIb)beta(3) and thrombus stability in vivo.
摘要
血小板中存在几种四跨膜蛋白，包括CD9、CD151、TSSC6和CD63。最近在基因敲除小鼠模型中的研究表明，CD151和TSSC6在体内对主要血小板整合素α(IIb)β(3)的“由外向内”信号特性调节及血栓稳定性方面存在物理和功能上的关联。
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