在抗HIV-1治疗中靶向病毒核衣壳蛋白。
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
作者信息
de Rocquigny Hugues, Shvadchak Volodymyr, Avilov Sergiy, Dong Chang Zhi, Dietrich Ursula, Darlix Jean-Luc, Mély Yves
机构信息
Institut Gilbert Laustriat, Photophysique des interactions moléculaires, UMR 7175 CNRS, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.
出版信息
Mini Rev Med Chem. 2008 Jan;8(1):24-35. doi: 10.2174/138955708783331603.
The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.
核衣壳蛋白（NC）在HIV复制过程中发挥着关键作用，因此是一个主要的药物靶点。NC的功能依赖于其两个锌指结构和侧翼碱性残基。锌离子排出剂可抑制NC的功能，但特异性有限。本文综述了与NC或其病毒核酸及酶伴侣竞争的新型分子。
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