Bush Ruth L, Kallen Michael A, Liles Debra R, Bates Jeffrey T, Petersen Laura A
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
J Surg Res. 2008 Apr;145(2):313-9. doi: 10.1016/j.jss.2007.03.022. Epub 2008 Jan 28.
Peripheral vascular disease (PVD), a manifestation of systemic atherosclerosis, is an independent risk factor for cardiovascular (CV) morbidity and mortality. PVD research has traditionally focused on male patients; thus, there is a lack of current studies focusing specifically on women. In a cross-sectional study, we assessed the prevalence of PVD and associated atherosclerotic risk factors in ambulatory women veterans as well as knowledge and awareness of PVD and its consequences.
We screened 162 ambulatory women veterans aged 40 to 85 who were enrolled for outpatient care at an urban, tertiary care, teaching hospital. Of 207 women who responded to advertisements or mailings about the study, 78.3% met eligibility criteria and gave informed consent to participate. The participants (N = 162, mean age 54.8 +/- 9.3 years) were evaluated via chart review and noninvasive screening procedures (ankle-brachial index [ABI]; carotid artery intimal-medial thickness [IMT]). PVD was defined by having an ABI <or=0.9, carotid IMT >1.0 mm, documented PVD, or previous leg revascularization. CV risk levels were determined using a modification of the Framingham risk level score: low risk, +0-1 risk factor; moderate risk, +2 risk factors; and high risk, >or=2 risk factors. Women's knowledge and awareness were assessed with a psychometrically sound survey (average subscale reliability: 0.942) about risk factors, symptoms, and health consequences associated with PVD.
Of 162 patients, 66.2% were white and 84.2% had at least some college education. An ABI <or=0.9 was detected in 3.7% of patients and a carotid IMT >1.0 mm was detected in 21.1%, while 1.2% had a prior diagnosis of PVD and 1.9% had previous leg revascularization. Risk factor stratification was as follows: low risk in 32.1%, moderate risk in 20.4%, and high risk in 47.5% of patients. Knowledge and awareness scores (% correct) for PVD were low regardless of CV risk factor group: low-risk average score was 45.7%; moderate risk, 42.1%; and high risk, 46.9% (F = 0.431, P = 0.650). Likewise, low scores for knowledge of CV risk factors and consequences were found in all CV risk factor groups: low-risk average score was 53.6%; moderate risk, 53.8%; and high risk, 54.4% (F = .013, P = 0.987). More than 68% of the women reported they had never discussed PVD or risk reduction with their physician, yet more than 44% believed they were at an increased risk for PVD.
Despite the presence of multiple PVD risk factors, women in this study had low levels of knowledge and awareness about vascular diseases. Future work is needed to develop and disseminate information about PVD in women and its role in women's CV health. Improving education about the significance of PVD will allow women and their physicians to assess risk factors and implement preventive measures.
外周血管疾病(PVD)是全身动脉粥样硬化的一种表现,是心血管(CV)发病和死亡的独立危险因素。PVD研究传统上聚焦于男性患者;因此,目前缺乏专门针对女性的研究。在一项横断面研究中,我们评估了非卧床女性退伍军人中PVD的患病率及相关动脉粥样硬化危险因素,以及她们对PVD及其后果的认知情况。
我们对162名年龄在40至85岁之间、在一家城市三级护理教学医院登记接受门诊治疗的非卧床女性退伍军人进行了筛查。在207名回应研究广告或邮件的女性中,78.3%符合入选标准并签署了知情同意书参与研究。参与者(N = 162,平均年龄54.8±9.3岁)通过病历审查和非侵入性筛查程序(踝臂指数[ABI];颈动脉内膜中层厚度[IMT])进行评估。PVD的定义为ABI≤0.9、颈动脉IMT>1.0 mm、有记录的PVD或既往腿部血管重建。使用改良的弗雷明汉风险评分来确定心血管风险水平:低风险,0至1个危险因素;中度风险,2个危险因素;高风险,≥2个危险因素。通过一项心理测量可靠的调查(平均子量表信度:0.942)评估女性对与PVD相关的危险因素、症状和健康后果的认知情况。
162名患者中,66.2%为白人,84.2%至少接受过一些大学教育。3.7%的患者检测到ABI≤0.9,21.1%检测到颈动脉IMT>1.0 mm,1.2%曾被诊断为PVD,1.9%有过腿部血管重建。危险因素分层如下:32.1%的患者为低风险,20.4%为中度风险,47.5%为高风险。无论心血管危险因素组如何,女性对PVD的认知得分(正确百分比)都很低:低风险组平均得分为45.7%;中度风险组为42.1%;高风险组为46.9%(F = 0.431,P = 0.650)。同样,在所有心血管危险因素组中,女性对心血管危险因素及其后果的认知得分也很低:低风险组平均得分为53.6%;中度风险组为53.8%;高风险组为54.4%(F = 0.013,P = 0.987)。超过68%的女性报告称她们从未与医生讨论过PVD或风险降低问题,但超过44%的女性认为自己患PVD的风险增加。
尽管存在多种PVD危险因素,但本研究中的女性对血管疾病的认知水平较低。未来需要开展工作,开发并传播有关女性PVD及其在女性心血管健康中作用的信息。提高对PVD重要性的教育将使女性及其医生能够评估危险因素并实施预防措施。