Bunte M C, Patnaik M M, Pritzker M R, Burns L J
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Bone Marrow Transplant. 2008 Apr;41(8):677-86. doi: 10.1038/sj.bmt.1705990. Epub 2008 Jan 28.
Veno-occlusive disease is among the most serious complications following hematopoietic stem cell transplantation. While hepatic veno-occlusive disease occurs more commonly, the pulmonary variant remains quite rare and often goes unrecognized antemortem. Endothelial damage may represent the pathophysiologic foundation of these clinical syndromes. Recent advances in the treatment of hepatic veno-occlusive disease may have application to its pulmonary counterpart.
静脉闭塞性疾病是造血干细胞移植后最严重的并发症之一。虽然肝静脉闭塞性疾病更为常见，但肺部型仍然相当罕见，且生前常未被识别。内皮损伤可能是这些临床综合征的病理生理基础。肝静脉闭塞性疾病治疗方面的最新进展可能适用于其肺部对应疾病。
