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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nobiling R, Gabel M, Persson P B, Dietrich M S, Bührle C P

I. Physiologisches Institut, Universität Heidelberg, Germany.

J Physiol. 1991 Dec;444:317-27. doi: 10.1113/jphysiol.1991.sp018880.

The effects of neuropeptide-Y (NPY) on the membrane potential of vascular smooth muscle cells were studied in renal arterioles of hydronephrotic mouse kidneys. 2. Kidney vessels are only weakly coupled with length constants of less than 10 microns and are most probably 'multiunit' vessels. 3. The vasoconstrictor peptide NPY reversibly depolarizes only smooth muscle cells in arterioles at distances greater than 200 microns from the glomerulus, whereas no changes of the membrane potential can be evoked close to the glomerulus (distance less than 50 microns). 4. The depolarizations, when present, are dose dependent. 5. Regardless of distance from the glomerulus cells respond uniformly to application of the vasoconstrictor angiotensin II.

研究了神经肽Y（NPY）对肾积水小鼠肾脏肾小动脉血管平滑肌细胞膜电位的影响。2. 肾血管的长度常数小于10微米，耦合较弱，很可能是“多单位”血管。3. 血管收缩肽NPY仅使距肾小球大于200微米处的小动脉平滑肌细胞可逆性去极化，而在靠近肾小球处（距离小于50微米）不能引起膜电位变化。4. 去极化现象（若存在）呈剂量依赖性。5. 无论距肾小球的距离如何，细胞对血管收缩剂血管紧张素II的应用反应均一致。

Nobiling R, Gabel M, Persson P B, Dietrich M S, Bührle C P

I. Physiologisches Institut, Universität Heidelberg, Germany.

J Physiol. 1991 Dec;444:317-27. doi: 10.1113/jphysiol.1991.sp018880.

The effects of neuropeptide-Y (NPY) on the membrane potential of vascular smooth muscle cells were studied in renal arterioles of hydronephrotic mouse kidneys. 2. Kidney vessels are only weakly coupled with length constants of less than 10 microns and are most probably 'multiunit' vessels. 3. The vasoconstrictor peptide NPY reversibly depolarizes only smooth muscle cells in arterioles at distances greater than 200 microns from the glomerulus, whereas no changes of the membrane potential can be evoked close to the glomerulus (distance less than 50 microns). 4. The depolarizations, when present, are dose dependent. 5. Regardless of distance from the glomerulus cells respond uniformly to application of the vasoconstrictor angiotensin II.

研究了神经肽Y（NPY）对肾积水小鼠肾脏肾小动脉血管平滑肌细胞膜电位的影响。2. 肾血管的长度常数小于10微米，耦合较弱，很可能是“多单位”血管。3. 血管收缩肽NPY仅使距肾小球大于200微米处的小动脉平滑肌细胞可逆性去极化，而在靠近肾小球处（距离小于50微米）不能引起膜电位变化。4. 去极化现象（若存在）呈剂量依赖性。5. 无论距肾小球的距离如何，细胞对血管收缩剂血管紧张素II的应用反应均一致。