Asensio Carlos, Zapata Ana, García-Ahijado Jesús, Gil Braulio, Salvadores Paloma, Schneider José
Hospital Nuestra Sra. Del Prado, Talavera de la Reina, Madrid, Spain.
Anticancer Res. 2007 Nov-Dec;27(6B):4083-6.
The role of apoptosis, and more specifically the Fas pathway, is still unclear in squamous cell laryngeal cancer.
By means of immunohistochemistry, the expression of three genes involved in different pathways of apoptosis (p53, Bcl-2 and Fas) was studied in a series of 45 squamous cell laryngeal cancers from Spanish patients.
Of the studied tumors, 25 (55.6%) expressed mutant p53, 22 (48.9%) expressed Bcl-2 and 25 (55.6%) expressed Fas. p53, Bcl-2 and Fas expression were not correlated with each other. The only tested factors associated with significantly better survival of the patients were low tumor stage (p = 0.0074), the absence of metastatic regional nodes (p = 0.0009) and Fas expression (p = 0.029). Fas expression was not correlated with the expression of any other tested parameter.
The determination of Fas expression in squamous cell laryngeal carcinoma by means of immunohistochemistry using the GM30/CD95 antibody could be of potential use in the clinic.
细胞凋亡的作用，尤其是Fas途径，在喉鳞状细胞癌中仍不清楚。
通过免疫组织化学方法，研究了一系列来自西班牙患者的45例喉鳞状细胞癌中参与不同细胞凋亡途径的三个基因（p53、Bcl-2和Fas）的表达。
在所研究的肿瘤中，25例（55.6%）表达突变型p53，22例（48.9%）表达Bcl-2，25例（55.6%）表达Fas。p53、Bcl-2和Fas的表达彼此不相关。与患者生存率显著提高相关的唯一测试因素是低肿瘤分期（p = 0.0074）、无区域淋巴结转移（p = 0.0009）和Fas表达（p = 0.029）。Fas表达与任何其他测试参数的表达均不相关。
使用GM30/CD95抗体通过免疫组织化学测定喉鳞状细胞癌中的Fas表达可能在临床上具有潜在用途。
