Pivonello Rosario, De Martino Maria Cristina, De Leo Monica, Lombardi Gaetano, Colao Annamaria
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Endocrinol Metab Clin North Am. 2008 Mar;37(1):135-49, ix. doi: 10.1016/j.ecl.2007.10.010.
Cushing's syndrome is a rare endocrine disease characterized by cortisol hypersecretion, induced mainly by a pituitary tumor (Cushing's disease) or, rarely, by an adrenal or an ectopic neuroendocine tumor. Cushing's syndrome is associated with severe morbidities and an increased mortality. The major systemic complications and the main cause of death are represented by cardiovascular disease. The prognosis of the disease is mainly affected by the difficulties in the diagnosis and treatment of the disease, which remain a considerable challenge.
库欣综合征是一种罕见的内分泌疾病，其特征为皮质醇分泌过多，主要由垂体肿瘤（库欣病）引起，或极少情况下由肾上腺或异位神经内分泌肿瘤引起。库欣综合征与严重疾病和死亡率增加相关。主要的全身并发症和主要死因是心血管疾病。该疾病的预后主要受疾病诊断和治疗困难的影响，这些困难仍然是一项重大挑战。
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