Volgger Birgit, Aspisirengil Coskun, Genser-Krimbacher Elisabeth, Ciresa-Koenig Alexandra, Daxenbichler Günter, Fuchs Dietmar, Windbichler Gudrun, Marth Christian
Medical University of Innsbruck, Department of Obstetrics and Gynaecology, Anichstrasse 35, 6020 Innsbruck, Austria.
Cancer Lett. 2008 Apr 18;262(2):183-9. doi: 10.1016/j.canlet.2007.12.005. Epub 2008 Jan 28.
Prognostic significance of squamous cell carcinoma antigen (SCC-Ag), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA) and neopterin in cervical cancer patients was compared.
Pretreatment concentrations were determined in 138 women.
Median age was 52 years, 85% squamous cell carcinomas, 15% adeno- or adenosquamous carcinomas were seen. In 36% Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, 24% stage II, 32% stage III and 8% stage IV was diagnosed. TPA was elevated in 22%, SCC in 68%, CEA in 42% and neopterin in 29%. These patients showed significantly worse overall survival in univariate analysis (p<0.001). TPA remained as independent prognostic factor in multivariate analysis.
Elevation of TPA was associated with worse overall survival.
比较了鳞状细胞癌抗原（SCC-Ag）、组织多肽抗原（TPA）、癌胚抗原（CEA）和新蝶呤在宫颈癌患者中的预后意义。
测定了138名女性的治疗前浓度。
中位年龄为52岁，其中85%为鳞状细胞癌，15%为腺癌或腺鳞癌。36%为国际妇产科联盟（FIGO）I期，24%为II期，32%为III期，8%为IV期。TPA升高者占22%，SCC升高者占68%，CEA升高者占42%，新蝶呤升高者占29%。单因素分析显示这些患者的总生存期明显较差（p<0.001）。多因素分析中TPA仍然是独立的预后因素。
TPA升高与较差的总生存期相关。
