组织多肽抗原（TPA）与鳞状细胞癌抗原（SCC-Ag）、癌胚抗原（CEA）及新蝶呤在子宫颈癌中的预后意义

Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix.

作者信息

Volgger Birgit, Aspisirengil Coskun, Genser-Krimbacher Elisabeth, Ciresa-Koenig Alexandra, Daxenbichler Günter, Fuchs Dietmar, Windbichler Gudrun, Marth Christian

机构信息

Medical University of Innsbruck, Department of Obstetrics and Gynaecology, Anichstrasse 35, 6020 Innsbruck, Austria.

出版信息

Cancer Lett. 2008 Apr 18;262(2):183-9. doi: 10.1016/j.canlet.2007.12.005. Epub 2008 Jan 28.

DOI:10.1016/j.canlet.2007.12.005

PMID:18226853

Abstract

INTRODUCTION

Prognostic significance of squamous cell carcinoma antigen (SCC-Ag), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA) and neopterin in cervical cancer patients was compared.

MATERIALS AND METHODS

Pretreatment concentrations were determined in 138 women.

RESULTS

Median age was 52 years, 85% squamous cell carcinomas, 15% adeno- or adenosquamous carcinomas were seen. In 36% Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, 24% stage II, 32% stage III and 8% stage IV was diagnosed. TPA was elevated in 22%, SCC in 68%, CEA in 42% and neopterin in 29%. These patients showed significantly worse overall survival in univariate analysis (p<0.001). TPA remained as independent prognostic factor in multivariate analysis.

CONCLUSIONS

Elevation of TPA was associated with worse overall survival.

摘要

引言

比较了鳞状细胞癌抗原（SCC-Ag）、组织多肽抗原（TPA）、癌胚抗原（CEA）和新蝶呤在宫颈癌患者中的预后意义。

材料与方法

测定了138名女性的治疗前浓度。

结果

中位年龄为52岁，其中85%为鳞状细胞癌，15%为腺癌或腺鳞癌。36%为国际妇产科联盟（FIGO）I期，24%为II期，32%为III期，8%为IV期。TPA升高者占22%，SCC升高者占68%，CEA升高者占42%，新蝶呤升高者占29%。单因素分析显示这些患者的总生存期明显较差（p<0.001）。多因素分析中TPA仍然是独立的预后因素。