Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
作者信息
Zhou Yuefen, Li Lian-Sheng, Dragovich Peter S, Murphy Douglas E, Tran Chinh V, Ruebsam Frank, Webber Stephen E, Shah Amit M, Tsan Mei, Averill April, Showalter Richard E, Patel Rupal, Han Qing, Zhao Qiang, Hermann Thomas, Kissinger Charles R, Lebrun Laurie, Sergeeva Maria V
机构信息
Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2008 Feb 15;18(4):1419-24. doi: 10.1016/j.bmcl.2008.01.005. Epub 2008 Jan 8.
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metabolic stability of this new class of compounds are also described.
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