仓鼠听觉惊跳反应的休克致敏和恐惧增强
Shock sensitization and fear potentiation of auditory startle response in hamsters.
作者信息
Sasaki Hitoshi, Hanamoto Atsushi
机构信息
Department of Physiology and Biosignaling (A5), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan.
出版信息
Percept Mot Skills. 2007 Dec;105(3 Pt 1):862-71. doi: 10.2466/pms.105.3.862-871.
It is well known that an auditory startle response can be modulated by several processes. In the present study shock sensitization and fear potentiation were examined in 17 hamsters to assess whether response enhancement is similar for another rodent. Immediately after presentation of electrical foot shocks, the auditory startle response increased significantly. This response was also enhanced after fear conditioning in the Experimental group using a light as a conditioned stimulus (CS) and the foot shock as the unconditioned stimulus (US). The auditory startle response remained unchanged in the Control group after nonpaired presentation of CS and US. Significant correlation between enhancement of the auditory startle response in sensitization and fear conditioning was found for the Experimental group. Shock sensitivity and effect of fear on modulation of the auditory startle response in hamsters are similar to those of other rodents. Further, neural mechanisms underlying enhancement of the auditory startle response seem not to be responsible for the deficit of prepulse inhibition in hamsters.
众所周知，听觉惊吓反应可受多种过程调节。在本研究中，对17只仓鼠进行了电击致敏和恐惧增强实验，以评估另一种啮齿动物的反应增强是否相似。在施加电足击后，听觉惊吓反应立即显著增加。在实验组中，使用光作为条件刺激（CS），足击作为非条件刺激（US）进行恐惧条件反射后，该反应也增强了。在对照组中，CS和US非配对呈现后，听觉惊吓反应保持不变。实验组在致敏和恐惧条件反射中听觉惊吓反应增强之间存在显著相关性。仓鼠的电击敏感性和恐惧对听觉惊吓反应调节的影响与其他啮齿动物相似。此外，听觉惊吓反应增强背后的神经机制似乎与仓鼠前脉冲抑制缺陷无关。
Zotero 插件