Vaughan R J, Vitali S D, Eden P A, Payne K L, Warren K S, Forshaw D, Friend J A, Horwitz A M, Main C, Krockenberger M B, Malik R
Veterinary Department, Perth Zoo, 20 Labouchere Road, South Perth, Western Australia 6151, Australia.
J Zoo Wildl Med. 2007 Dec;38(4):567-73. doi: 10.1638/2007-0005R.1.
Two cases of fatal cryptococcosis are described, one of Cryptococcus neoformans infection in a Gilbert's potoroo (Potorous gilbertii) and one of Cryptococcus gattii infection in a long-nosed potoroo (Potorous tridactylus). The diagnoses were confirmed by culture and specific immunohistochemistry, respectively. The long-nosed potoroo tested positive using the latex cryptococcal antigen test (LCAT), whereas the Gilbert's potoroo had a negative LCAT result despite having advanced disease of some duration. In both cases, the clinical presentation was a progressive neurologic disease associated with a central nervous system infection. Pulmonary infection was also observed in the long-nosed potoroo. Specific treatment with antifungal agents was unsuccessful in the long-nosed potoroo.
本文描述了两例致命的隐球菌病病例，一例是吉尔伯特袋鼠（Potorous gilbertii）感染新型隐球菌，另一例是长鼻袋鼠（Potorous tridactylus）感染加氏隐球菌。诊断分别通过培养和特异性免疫组织化学得到证实。长鼻袋鼠使用乳胶隐球菌抗原试验（LCAT）检测呈阳性，而吉尔伯特袋鼠尽管患有持续一段时间的晚期疾病，但LCAT结果为阴性。在这两个病例中，临床表现均为与中枢神经系统感染相关的进行性神经疾病。在长鼻袋鼠中还观察到肺部感染。长鼻袋鼠使用抗真菌药物进行特异性治疗未成功。
