Takeda Takashi, Sakata Masahiro, Isobe Aki, Miyake Asako, Nishimoto Fumihito, Ota Yukinobu, Kamiura Shouji, Kimura Tadashi
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Gynecol Obstet Invest. 2008;66(1):14-7. doi: 10.1159/000114250. Epub 2008 Jan 30.
BACKGROUND/AIMS: Uterine leiomyomas are the most common gynecological benign tumor and greatly affect reproductive health and well-being. The pathophysiology and epidemiology of fibroids are poorly understood. Obesity and elevated blood pressure have been reported to be predisposing factors. In this study, we investigated whether fibroids are associated with some criteria of the metabolic syndrome.
The case patients were 213 women who underwent hysterectomy or myomectomy for fibroids, and the control subjects were 159 women who underwent operation for benign indications other than fibroids. Preoperative information on body mass index (BMI), blood pressure (BP), serum triglyceride (TG) and fasting plasma glucose (FPG) was obtained from medical records. The patients were classified as overweight if they had a preoperatively measured BMI of > or =24.0, hypertensive if BP was > or =140/90 mm Hg, hypertriglyceridemic if TG was > or =150 mg/dl, and hyperglycemic if FPG was > or =110 mg/dl.
BMI, BP, TG and FPG were significantly higher in the case group compared with the control group. In logistic regression analysis, fibroids were statistically significantly associated with being overweight and hypertensive. With the combination of these risk factors, the risk of fibroids increased.
Uterine leiomyomas may share pathogenic features with the development of metabolic syndrome.
背景/目的：子宫肌瘤是最常见的妇科良性肿瘤，严重影响生殖健康和生活质量。目前对子宫肌瘤的病理生理学和流行病学了解甚少。据报道，肥胖和高血压是其诱发因素。在本研究中，我们调查了子宫肌瘤是否与代谢综合征的某些标准相关。
病例组为213例因子宫肌瘤接受子宫切除术或肌瘤切除术的女性，对照组为159例因非肌瘤的良性疾病接受手术的女性。从病历中获取术前体重指数（BMI）、血压（BP）、血清甘油三酯（TG）和空腹血糖（FPG）的信息。术前测量的BMI≥24.0者为超重，BP≥140/90 mmHg者为高血压，TG≥150 mg/dl者为高甘油三酯血症，FPG≥110 mg/dl者为高血糖。
病例组的BMI、BP、TG和FPG显著高于对照组。在逻辑回归分析中，子宫肌瘤与超重和高血压在统计学上显著相关。这些危险因素共同作用时，患子宫肌瘤的风险增加。
子宫肌瘤可能与代谢综合征的发生具有共同的致病特征。
