Shay J W, Keith W N
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9030, USA.
Br J Cancer. 2008 Feb 26;98(4):677-83. doi: 10.1038/sj.bjc.6604209. Epub 2008 Jan 29.
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.
晚期恶性肿瘤的标志之一是细胞持续生长,这几乎普遍与端粒酶的重新激活相关。尽管我们对端粒酶的调控仍有很多不了解之处,但它仍然是癌症治疗中一个非常有吸引力的新靶点。已经开展了多项临床试验,在本综述中,我们重点介绍一些最有前景的方法,并通过推测端粒酶在癌症干细胞中的作用来进行总结。