Stringer Elizabeth M, Chi Benjamin H, Chintu Namwinga, Creek Tracy L, Ekouevi Didier K, Coetzee David, Tih Pius, Boulle Andrew, Dabis Francois, Shaffer Nathan, Wilfert Catherine M, Stringer Jeffrey S A
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Bull World Health Organ. 2008 Jan;86(1):57-62. doi: 10.2471/blt.07.043117.
Ambitious goals for paediatric AIDS control have been set by various international bodies, including a 50% reduction in new paediatric infections by 2010. While these goals are clearly appropriate in their scope, the lack of clarity and consensus around how to monitor the effectiveness of programmes to prevent mother-to-child HIV transmission (PMTCT) makes it difficult for policy-makers to mount a coordinated response. In this paper, we develop the case for using population HIV-free child survival as a gold standard metric to measure the effectiveness of PMTCT programmes, and go on to consider multiple study designs and source populations. Finally, we propose a novel community survey-based approach that could be implemented widely throughout the developing world with minor modifications to ongoing Demographic and Health Surveys.
包括到2010年将新增儿童感染病例减少50%在内,各国际机构已为儿科艾滋病防治设定了宏伟目标。虽然这些目标在范围上显然是恰当的,但在如何监测预防母婴传播艾滋病毒(PMTCT)项目的有效性方面缺乏明确性和共识,这使得政策制定者难以做出协调一致的应对举措。在本文中,我们阐述了将无艾滋病毒儿童的群体存活率作为衡量PMTCT项目有效性的黄金标准指标的理由,并进而考虑了多种研究设计和源人群。最后,我们提出了一种基于社区调查的全新方法,只需对现行的人口与健康调查稍作修改,便可在整个发展中世界广泛实施。