Qi Rui-feng, Zhang Ling, Chi Cheng-wu
Institute of Protein Research, Tongji University, Shanghai 200092, China.
Acta Biochim Biophys Sin (Shanghai). 2008 Feb;40(2):91-101. doi: 10.1111/j.1745-7270.2008.00382.x.
Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been particularly prevalent in India, Southeast Asia, Brazil, and Guangdong Province, China. In this article, we present a brief summary of the biological characteristics of dengue virus and associated flaviviruses, and outline the progress on studies of vaccines and drugs based on potential targets of the dengue virus.
登革热感染是热带和亚热带地区发病的主要原因，使全球近40%的人口面临风险，每年导致超过2万例死亡。但目前既没有登革热疾病的疫苗，也没有治疗该感染的抗病毒药物。近年来，登革热感染在印度、东南亚、巴西以及中国广东省尤为流行。在本文中，我们简要概述了登革病毒及相关黄病毒的生物学特性，并基于登革病毒的潜在靶点概述了疫苗和药物的研究进展。
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