Gessmann R, Brueckner H, Kokkinidis M
IMBB/FORTH Crete, Greece.
Pept Res. 1991 Jul-Aug;4(4):239-44.
Z-Aib-Gly-Aib-Leu-Aib-OtBu, the alpha-aminoisobutyric acid (Aib)-containing N-terminal pentapeptide of the antibiotic trichotoxin, has been studied by x-ray crystallography. The molecule forms a right-handed helix with a reversal of the sense of the helix at the C-terminus. Torsion angles and hydrogen bonding pattern are consistent with a mixed 3(10)-/alpha-helical conformation. In the crystal, continuous columns are formed by head-to-tail arrangement of hydrogen-bonded molecules along the helix axis. The helical columns associate via hydrogen bonds forming closely packed parallel pairs.
Z-Aib-Gly-Aib-Leu-Aib-OtBu，即抗生素trichotoxin含α-氨基异丁酸（Aib）的N端五肽，已通过X射线晶体学进行了研究。该分子形成一个右手螺旋，在C端螺旋方向发生反转。扭转角和氢键模式与混合的3(10)-/α-螺旋构象一致。在晶体中，通过沿螺旋轴氢键连接的分子头对尾排列形成连续的柱体。螺旋柱通过氢键结合形成紧密堆积的平行对。
