Frank Stuart J
Department of Cell Biology and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA.
J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):119-29. doi: 10.1007/s10911-008-9065-9. Epub 2008 Jan 31.
Growth hormone (GH) and prolactin (PRL) are anterior pituitary hormones that have multiple roles in growth and metabolism. Both hormones are important in mammary development and breast cancer. The epidermal growth factor (EGF) family of peptides and the receptors that they activate (the ErbB family) are also major players in mammary biology and pathophysiology. Recent studies in signal transduction have highlighted the interplay between signaling pathways referred to as crosstalk. In this review, cell biological and signaling studies related to crosstalk between GH and PRL and the ErbB family are discussed. In particular, the role of GH- and PRL-induced phosphorylation of ErbB receptors in regulating EGF responsiveness is highlighted with attention to potential pathophysiological relevance.
生长激素（GH）和催乳素（PRL）是垂体前叶激素，在生长和代谢中发挥多种作用。这两种激素在乳腺发育和乳腺癌中都很重要。表皮生长因子（EGF）肽家族及其激活的受体（ErbB家族）也是乳腺生物学和病理生理学的主要参与者。最近在信号转导方面的研究突出了被称为串扰的信号通路之间的相互作用。在这篇综述中，讨论了与GH和PRL以及ErbB家族之间串扰相关的细胞生物学和信号研究。特别强调了GH和PRL诱导的ErbB受体磷酸化在调节EGF反应性中的作用，并关注其潜在的病理生理相关性。
