用脱氧鸟苷预处理提高胰岛同种异体移植的存活率。
Improvement in allograft survival of islets of Langerhans by pretreatment with deoxyguanosine.
作者信息
al-Abdullah I H, Kumar M S, al-Adnani M S, Abouna G M
机构信息
Department of Surgery, Hahnemann University, Philadelphia, Pennsylvania 19102.
出版信息
Diabetes Res. 1991 Aug;17(4):181-7.
PMID:1823639
Abstract
In vitro pretreatment of isolated islets of Langerhans prior to transplantation with deoxyguanosine (dGuo) was found to be effective in improving the survival in fully allogeneic diabetic rats (Wistar----PVG). Post transplant immunosuppression was not used. Islets pretreated with various concentrations of dGuo, 1, 1.35, 1.5 and 2 microM dGuo per islet showed a graft survival of 9, 36, 9 and 14% respectively.
摘要
在将分离的胰岛移植到完全异基因糖尿病大鼠（Wistar-PVG）体内之前，用脱氧鸟苷（dGuo）进行体外预处理被发现可有效提高胰岛在大鼠体内的存活率。移植后未使用免疫抑制措施。用不同浓度的dGuo（每个胰岛分别为1、1.35、1.5和2微摩尔dGuo）预处理的胰岛，其移植存活率分别为9%、36%、9%和14%。
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