制霉菌素抗性麦芽糖假丝酵母突变体的甾醇组成
Sterol composition of nystatin-resistant Candida maltosa mutants.
作者信息
Mikhailova N P, Sorokoletova E F, Durasova E N, Vyunov K A, Shapovalov O I
机构信息
All-Union Institute of Plant Material Hydrolysis, Leningrad, USSR.
出版信息
Folia Microbiol (Praha). 1991;36(2):148-52. doi: 10.1007/BF02814494.
Composition of sterol fractions of nystatin-resistant Candida maltosa strains was determined. Using UV-spectrometry, TLC and GLC-MS it was demonstrated that resistance to nystatin is connected with the composition alterations of yeast cell sterols. Block of different stages of ergosterol biosynthesis was revealed in some mutants, viz. C-24-transmethylation, delta 8----delta 7-isomerization, 14 alpha-demethylation, C-5(6)-dehydrogenation, reduction of C-14(15) and C-24(28) double bonds.
测定了耐制霉菌素的麦芽糖假丝酵母菌株甾醇组分的组成。通过紫外光谱法、薄层色谱法和气相色谱 - 质谱联用技术表明，对制霉菌素的抗性与酵母细胞甾醇的组成变化有关。在一些突变体中发现了麦角甾醇生物合成不同阶段的阻断，即C - 24 - 甲基转移、δ8→δ7 - 异构化、14α - 去甲基化、C - 5(6) - 脱氢、C - 14(15)和C - 24(28)双键的还原。
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