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通过对异丙肾上腺素和多巴酚丁胺的变时性、变力性及环磷酸腺苷反应评估心房和心室组织的β肾上腺素能敏感性差异

Differential beta adrenergic sensitivity of atrial and ventricular tissue assessed by chronotropic, inotropic, and cyclic AMP responses to isoprenaline and dobutamine.

作者信息

Tuttle R R, Hillmann C C, Toomey R E

出版信息

Cardiovasc Res. 1976 Jul;10(4):452-8. doi: 10.1093/cvr/10.4.452.

DOI:10.1093/cvr/10.4.452
PMID:182368
Abstract

Cat atrial tissue was more sensitive to isoprenaline (USP:isoproterenol) and dobutamine than ventricular tissue. Chronotropic response of atrial strips occurred at lower agonist concentrations than inotropic responses of papillary muscle. Cyclic AMP responses in atrial slices also occurred at lower agonist concentrations and were of much greater magnitude than the cyclic AMP responses in ventricular slices. However, the disporportionately greater sensitivity of atrial tissue was more marked with isoprenaline than with dobutamine.

摘要

猫心房组织对异丙肾上腺素(美国药典:异丙肾上腺素)和多巴酚丁胺的敏感性高于心室组织。心房条带的变时反应在激动剂浓度低于乳头肌的变力反应时出现。心房切片中的环磷酸腺苷反应也在较低的激动剂浓度下发生,并且其幅度比心室切片中的环磷酸腺苷反应大得多。然而,心房组织不成比例的更高敏感性在异丙肾上腺素作用下比在多巴酚丁胺作用下更为明显。

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