突尼斯特应性皮炎患者的HLA - A、B、DR和DQ等位基因研究。
HLA- A, B, DR and DQ alleles study in Tunisian patients with atopic dermatitis.
作者信息
Affes Hanene, Mahfoudh Nedia, Kammoun Arwa, Masmoudi Abdelrahmen, Marrekchi Saleheddine, Turki Hamida, Makni Hafedh
机构信息
Service de laboratoire, CHU Hedi chaker, Sfax, Tunisia.
出版信息
Tunis Med. 2007 Oct;85(10):834-8.
BACKGROUND
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from the interaction between envirommental and genetic factors. Many genes are involved in the etiopathology of AD, such as HLA genes.
OBJECTIVES
Study the association between HLA-A, B, DR and DQ genes and the AD.
METHODS
HLA A and B genotyping were practised for 53 atopic dermatitis patients and 76 healthy controls using the microlymphotoxicity complement dependent technique, while HLA DR and DQ genetyping were practised for only 20 patients with AD and all the controls by PCR-SSP method.
RESULTS
Allelic frequency of HLA A32 was significantly increased in healthy individuals compared to patients affected with AD (p = 0.02, RR = 0.24). HLA-B, DR and DQ showed no differences in distrubition between patients and controls.
CONCLUSION
Our study suggested that HLA-A32 could be a protective marker against atopic dermatitis for Tunisian patients, in contrast to HLA-B, DR and DQ alleles which seemed to have no importance in AD pathogenis.
背景
特应性皮炎（AD）是一种由环境因素和遗传因素相互作用导致的慢性炎症性皮肤病。许多基因参与了AD的发病机制，如HLA基因。
目的
研究HLA - A、B、DR和DQ基因与AD之间的关联。
方法
采用微量淋巴细胞毒补体依赖技术对53例特应性皮炎患者和76例健康对照进行HLA A和B基因分型，而仅对20例AD患者和所有对照采用PCR - SSP方法进行HLA DR和DQ基因分型。
结果
与AD患者相比，健康个体中HLA A32的等位基因频率显著升高（p = 0.02，RR = 0.24）。HLA - B、DR和DQ在患者和对照之间的分布没有差异。
结论
我们的研究表明，对于突尼斯患者，HLA - A32可能是特应性皮炎的一个保护标志物，而HLA - B、DR和DQ等位基因在AD发病机制中似乎没有重要作用。
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