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[同种异体淋巴细胞对干细胞的失活作用:T1和T2亚群之间的竞争]

[Inactivation of stem cells by allogenic lymphocytes: competition between T1- and T2-subpopulations].

作者信息

Ignat'eva G A, Man'ko V M, Rudneva T B

出版信息

Biull Eksp Biol Med. 1977 Jun;83(6):709-11.

PMID:18238
Abstract

Transplantation of the bone marrow cells with allogeneic T-lymphocytes to the irradiated hosts was accompanied by inactivation of the stem elements of the graft. The lymph node cells of T-mice (those deprived of B cells) were more active than the spleen cells of these mice. The stem cells inactivation was weakly expressed or absent in case of a combined acti-n of T-cells from the lymph nodes and the spleen.

摘要

将含有同种异体T淋巴细胞的骨髓细胞移植到受照射的宿主体内,会伴随着移植物干细胞成分的失活。T小鼠(缺乏B细胞的小鼠)的淋巴结细胞比这些小鼠的脾细胞更活跃。在淋巴结和脾脏的T细胞联合作用的情况下,干细胞失活表现较弱或不存在。

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