Trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals.

A trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals is proposed. Concentrations of ethoxybenzamide in rat tissues and diazepam in human plasma were simulated. The results showed that profiles of concentrations vs time in the body with this method were in a good agreement with those obtained with the Rang-Katta method. As compared with the Rang-Katta method, the present method has two special advantages: the time course of drug concentration in tissue can be estimated using simple equations and the speed for simulation is faster.