妊娠期血栓性血小板减少性紫癜合并短暂性严重胎儿心率异常。
Transient severe fetal heart rate abnormalities in a pregnancy complicated by thrombotic thrombocytopenic purpura.
作者信息
Strasser Sanne M, Kwee Anneke, Fijnheer Rob, Visser Gerard H A
机构信息
Departments of Obstetrics and Gynecology, and Hematology, University Medical Centre Utrecht, Utrecht, The Netherlands.
出版信息
Obstet Gynecol. 2008 Feb;111(2 Pt 2):517-21. doi: 10.1097/01.AOG.0000267216.18493.08.
BACKGROUND
Thrombotic thrombocytopenic purpura is a rare disease. However, in pregnant women it occurs more frequently. Thrombotic thrombocytopenic purpura may be a severe condition for both mother and fetus.
CASE
This is a case of severe but temporary fetal heart rate abnormalities in a pregnancy complicated by thrombotic thrombocytopenic purpura. There was a remarkably good outcome despite indications of an impaired fetal condition for a period of at least 48 hours.
CONCLUSION
Based on the literature regarding transient severe neurological symptoms in adults with thrombotic thrombocytopenic purpura, we hypothesize that the transient fetal heart rate abnormalities were most likely due to reversible microthrombi in the placenta.
背景
血栓性血小板减少性紫癜是一种罕见疾病。然而，它在孕妇中更频繁发生。血栓性血小板减少性紫癜对母亲和胎儿来说都可能是一种严重病症。
病例
这是一例妊娠合并血栓性血小板减少性紫癜时出现严重但短暂的胎儿心率异常的病例。尽管在至少48小时的一段时间内有胎儿状况受损的迹象，但结局非常良好。
结论
基于有关成人血栓性血小板减少性紫癜的短暂严重神经症状的文献，我们推测短暂的胎儿心率异常很可能是由于胎盘中可逆性微血栓形成所致。
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