Udvardy M, Telek B, Kiss A, Flóra Nagy M, Mikó T, Rák K
Debreceni Orvostudományi Egyetem, II. sz. Belgyógyászati Klinika.
Orv Hetil. 1990 Apr 14;131(15):787-8, 791.
The appearance of thrombotic microangiopathy (thrombotic thrombocytopenic purpura, haemolytic uraemic syndrome) could have been documented in a 23 years old pregnant woman, who had been treated previously for immune-thrombocytolytic purpura. The disturbing anamnestic data caused significant delay in correct diagnosis and in starting of fresh-frozen plasma therapy, so the woman and her fetus (in utero) had been died. The specific histological microangiopathic lesions could have been well documented by the autopsy of the mother, however no such alterations could have been detected in the fetus and placenta. This latter intriguing observation might be remarkable in the evaluation of several concepts dealing with the aetiopathogenesis of thrombotic microangiopathy. The short review of literature of thrombotic microangiopathy in pregnancy and puerperial period is also given.
一名23岁的孕妇曾因免疫性血小板减少性紫癜接受过治疗，现出现血栓性微血管病（血栓性血小板减少性紫癜、溶血性尿毒症综合征）。令人不安的既往病史导致正确诊断和开始新鲜冷冻血浆治疗出现显著延迟，因此该名妇女及其胎儿（宫内）均死亡。母亲的尸检能够很好地记录特定的组织学微血管病变，但在胎儿和胎盘中未检测到此类改变。后一有趣的观察结果在评估有关血栓性微血管病发病机制的几个概念时可能具有重要意义。本文还对妊娠和产褥期血栓性微血管病的文献进行了简要综述。
