Olguín Hugo Juárez, Asseff Ismael Lares, Vieyra Angélica Camacho, Pérez Adrián Guillé, Saldaña Napoleón González, Quesada Argelia Camarillo, Guillé Gabriela Pérez
Laboratorio de Farmacología, Instituto Nacional de Pediatría, Colonia Insurgentes Cuicuilco, Mexico City, Mexico.
Biol Pharm Bull. 2008 Feb;31(2):316-20. doi: 10.1248/bpb.31.316.
The aim of the present study was to investigate if the severity of illness affected the pharmacokinetics of cefuroxime in 11 children diagnosed with multiple organ system failure. The patients were assigned to a severely ill group (group 1), a very severely ill group (group 2), or a control group (group 0). Blood samples were taken and cefuroxime concentrations were measured in plasma by HPLC after the first intravenous infusion of 100 mg of cefuroxime per kg of body weight. The pharmacokinetic profile of cefuroxime exhibited both one and two compartmental distribution. Statistically significant differences between the pharmacokinetic parameters of the severe (group 1) and the very severe patients (group 2) were found, and significant differences (p<0.05) in the pharmacokinetic parameters between groups 1 and 2 vs. the control group were observed for most of the parameters analyzed. However, there was no statistical difference in clearance between group 1 and the control group. The data indicate that the pharmacokinetic differences determined by severity of disease are useful for establishing an individualized regimen dosage in children with multiple organ system failure.
本研究的目的是调查疾病严重程度是否会影响11名被诊断为多器官系统衰竭的儿童中头孢呋辛的药代动力学。这些患者被分为重症组（1组）、极重症组（2组）或对照组（0组）。在首次静脉输注每千克体重100毫克头孢呋辛后，采集血样并用高效液相色谱法测定血浆中头孢呋辛的浓度。头孢呋辛的药代动力学特征呈现一室和二室分布。发现重症（1组）和极重症患者（2组）的药代动力学参数之间存在统计学显著差异，并且在分析的大多数参数中，观察到1组和2组与对照组之间的药代动力学参数存在显著差异（p<0.05）。然而，1组和对照组之间的清除率没有统计学差异。数据表明，由疾病严重程度决定的药代动力学差异有助于为多器官系统衰竭的儿童建立个体化的用药方案剂量。
