Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.
作者信息
Gitto Rosaria, Francica Eleonora, De Sarro Giovambattista, Scicchitano Francesca, Chimirri Alba
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Università di Messina, Messina, Italy.
出版信息
Chem Pharm Bull (Tokyo). 2008 Feb;56(2):181-4. doi: 10.1248/cpb.56.181.
PMID:18239304
Abstract
Following our previous studies in the field of anticonvulsant agents, we planned a one-pot solution-phase parallel synthesis (SPPS) of a small library of new 1,2,3,4-tetrahydroisoquinoline derivatives. The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated.
摘要
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