Anikina T A, Bilalova G A, Zverev A A, Sitdikov F G
Department of Anatomy, Physiology, and Human Health Protections, Kazan State Liberal Pedagogical University.
Bull Exp Biol Med. 2007 Jun;143(6):695-8. doi: 10.1007/s10517-007-0217-5.
Stable agonist of P2 receptors 2-methylthio-ATP and selective antagonists of P2X and P2Y receptors PPADS and reactive blue-2 were used for evaluation of the role of P2 receptors in positive contractile reaction of atrial and ventricular myocardium in rats. PPADS significantly moderated the effects of 2-methylthio-ATP in 14-, 21-, and 56-day-old rat pups, but potentiated them in 100-day-old rats. Under conditions of reactive blue-2 treatment, the positive effect of the agonist was preserved in the atria and ventricles in all age groups and was age-dependent.
