[环孢素A在肾移植患者输注后的药代动力学]
[Pharmacokinetics of cyclosporin A in renal transplant patients after infusion].
作者信息
Gu C N, Deng Y L, Zhu Y H, Zhu C J, Gu Q P
机构信息
Department of Clinical Pharmacology, Changzheng Hospital, Shanghai, China.
出版信息
Zhongguo Yao Li Xue Bao. 1991 Nov;12(6):528-30.
PMID:1824006
Abstract
Seventeen patients after renal transplantation were infused iv cyclosporin A (CsA) 0.65 +/- 0.13 mg.kg-1.h-1. Blood CsA was determined by fluorescence polarization immunoassay (FPIA). Pharmacokinetic parameters were calculated from micro-computer pharmacokinetic programme T1/2 beta = 8.6 +/- 3.4 h, Vd = 3.2 +/- 1.3 L.kg-1. No significant difference was found between sexes and between age groups.
摘要
17例肾移植患者静脉输注环孢素A（CsA），剂量为0.65±0.13mg·kg⁻¹·h⁻¹。采用荧光偏振免疫分析法（FPIA）测定血中环孢素A浓度。通过微型计算机药代动力学程序计算药代动力学参数，T1/2β = 8.6±3.4小时，Vd = 3.2±1.3L·kg⁻¹。性别和年龄组之间未发现显著差异。
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