Scheithauer Bernd W, Rodriguez Fausto J, Spinner Robert J, Dyck P James, Salem Ayman, Edelman Fredric L, Amrami Kimberly K, Fu Yao-Shi
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Neurosurg. 2008 Feb;108(2):348-56. doi: 10.3171/JNS/2008/108/2/0348.
As a rule, normal human nerve does not contain glomus bodies. Nonetheless, rare examples of glomus tumors do arise in peripheral nerves of various sizes. Their pathobiological characteristics are poorly understood, but reported examples have been small and clinically benign. The authors identified in 1 patient each a glomus tumor and a glomangioma involving nerve. Clinical histories as well as imaging and surgical findings were reviewed. All available H & E-stained slides were examined in both cases. Immunohistochemical stains and electron microscopy, as appropriate, were also performed. The lesions were subtotally and completely resected, respectively. An uneventful postoperative recovery was noted in both patients. Glomus tumors and glomangiomas can involve major nerves on rare occasions. They seem to follow a favorable clinical course, and conservative resection can be of benefit.
通常情况下，正常人类神经不包含球旁体。然而，各种大小的周围神经中确实会出现罕见的球瘤病例。它们的病理生物学特征了解甚少，但已报道的病例体积较小且临床呈良性。作者在1例患者中分别发现了累及神经的球瘤和血管球瘤。回顾了临床病史以及影像学和手术结果。对两例病例中所有可用的苏木精和伊红染色切片进行了检查。还酌情进行了免疫组织化学染色和电子显微镜检查。病变分别进行了次全切除和全切除。两名患者术后恢复均顺利。球瘤和血管球瘤在罕见情况下可累及主要神经。它们似乎具有良好的临床病程，保守性切除可能有益。
