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[Balb/c小鼠正常淋巴细胞中核苷酸焦磷酸酶和磷酸水解酶活性的证明以及YC8肿瘤细胞和患有YC8淋巴瘤动物的淋巴细胞中这些活性的缺失]

[Demonstration of nucleotide pyrophosphatase and phosphohydrolase activities in normal lymphocyte of Balb/c mice and absence of these activities in YC8 tumor cells and in lymphocytes of animals with YC8 lymphoma].

作者信息

Barel-Ramniceanu M, Morel E

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Jun 14;282(22):1999-2002.

PMID:182410
Abstract

Saline extraction of tumor cells from YC8 lymphoma transplanted in Balb/c Mice, of lymphocytes from animals bearing this tumor and of lymphocytes from control animals, allowed us to show important hydrolytic activities towards UDP-[(14C)]-galactose and galactose-[(14C)]-1-phosphate in normal lymphocytes. These activities disappear in lymphocytes from Mice bearing this tumor and in tumor cells themselves.

摘要

从移植于Balb/c小鼠的YC8淋巴瘤中提取肿瘤细胞、从患有该肿瘤的动物体内提取淋巴细胞以及从对照动物体内提取淋巴细胞,经生理盐水处理后,我们发现正常淋巴细胞对UDP-[(14C)]-半乳糖和半乳糖-[(14C)]-1-磷酸具有重要的水解活性。而在患有该肿瘤的小鼠的淋巴细胞以及肿瘤细胞本身中,这些活性消失。

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