Weiser M, Reichenberg A, Werbeloff N, Kravitz E, Halperin D, Lubin G, Shmushkevitch M, Yoffe R, Addington J, Davidson M
Department of Psychiatry, Sheba Medical Center, Tel-Hashomer, Israel.
Acta Psychiatr Scand. 2008 Mar;117(3):225-31. doi: 10.1111/j.1600-0447.2007.01143.x. Epub 2008 Jan 30.
Previous studies indicate that a poor family environment might affect vulnerability for the later manifestation of psychotic illness. The current study aims to examine family functioning prior to the onset of psychosis.
Subjects were 42,948, 17-year old males with behavioural disturbances who were asked about the functioning of their family by the Israeli Draft Board. Data on later psychiatric hospitalizations were obtained from a National Psychiatric Hospitalization Registry.
Poorer self-reported family functioning was associated with greater risk for later hospitalization for psychosis [adjusted hazard ratio (HR) = 1.16, 95% CI = 1.05-1.27], with a trend in the same direction for schizophrenia (adjusted HR = 1.1, 95% CI = 0.98-1.24).
In male adolescents with behavioural disturbances, perceived poorer family functioning is associated with increased risk for non-affective psychotic disorders and schizophrenia. These data do not enable us to determine if perceived familial dysfunction increases vulnerability for psychosis, if premorbid behavioural abnormalities disrupt family life, or neither.
既往研究表明,不良的家庭环境可能会影响日后患精神病的易感性。本研究旨在调查精神病发作前的家庭功能。
研究对象为42948名17岁有行为障碍的男性,以色列征兵委员会询问了他们家庭功能的情况。后来的精神病住院数据来自国家精神病住院登记处。
自我报告的家庭功能较差与日后因精神病住院的风险较高相关[调整后的风险比(HR)=1.16,95%可信区间(CI)=1.05-1.27],精神分裂症也有相同方向的趋势(调整后的HR=1.1,95%CI=0.98-1.24)。
在有行为障碍的男性青少年中,感知到的较差家庭功能与非情感性精神病性障碍和精神分裂症的风险增加有关。这些数据无法让我们确定是感知到的家庭功能障碍增加了患精神病的易感性,还是病前行为异常扰乱了家庭生活,或者两者都不是。