Welham Joy, Scott James, Williams Gail, Najman Jake, O'Callaghan Michael, McGrath John
Queensland Centre for Mental Health Research, Park Centre for Mental Health, Queensland, Australia.
Aust N Z J Psychiatry. 2009 Jan;43(1):61-7. doi: 10.1080/00048670802534333.
While birth cohort studies have shown that individuals who develop non-affective psychosis show subtle deviations in cognitive and behavioural developmental trajectories, there is less evidence about deviations in physical growth in these individuals. The purpose of the present study was to examine the association between behaviour and growth and maturation from infancy, through childhood and adolescence to early adulthood and the development of non-affective psychosis in young adults.
Based on a birth cohort of 3801 young adults, weight and length/height were examined at birth and at years 5, 14 and 21, together with pubertal maturation at year 14. Behavioural measures taken at years 5 and 14 were also examined. Screen-positive non-affective psychosis (SP-NAP) was assessed at year 21 using Composite International Diagnostic Interview, or a self-report checklist. The association between the behavioural and growth measures at birth and at years 5, 14 and 21, and SP-NAP at year 21 was examined using logistic regression.
There were 60 subjects in the cohort who were classified as having SP-NAP. In female subjects SP-NAP was significantly associated with being longer with a larger head circumference at birth, and less likely to be associated with being shorter at 21 years, with consistent trend associations for height between. There were no differences for weight. There was no significant association between the variables of interest in male subjects or for the total group. There was also no significant association between pubertal development at age 14 and risk of SP-NAP in either sex.
Unlike developmental behavioural problems, which showed continuity from childhood through adolescence, SP-NAP was not associated with marked deviations in growth trajectory for male subjects, but the present data suggests that female subjects with SP-NAP had an altered skeletal growth trajectory.
虽然出生队列研究表明，患非情感性精神病的个体在认知和行为发展轨迹上存在细微偏差，但关于这些个体身体生长偏差的证据较少。本研究的目的是探讨从婴儿期、儿童期、青少年期到成年早期的行为与生长发育以及年轻成年人非情感性精神病发展之间的关联。
基于一个有3801名年轻成年人的出生队列，在出生时、5岁、14岁和21岁时测量体重和身长/身高，并在14岁时测量青春期发育情况。还对5岁和14岁时采取的行为测量指标进行了检查。在21岁时使用综合国际诊断访谈或自我报告清单评估筛查阳性的非情感性精神病（SP-NAP）。使用逻辑回归分析出生时、5岁、14岁和21岁时的行为和生长测量指标与21岁时的SP-NAP之间的关联。
该队列中有60名受试者被归类为患有SP-NAP。在女性受试者中，SP-NAP与出生时身长较长、头围较大显著相关，而与21岁时身高较矮的相关性较小，身高之间存在一致的趋势关联。体重方面无差异。男性受试者或整个组中感兴趣的变量之间无显著关联。14岁时的青春期发育与任何性别中SP-NAP的风险之间也无显著关联。
与从童年到青少年期具有连续性的发育行为问题不同，SP-NAP与男性受试者的生长轨迹明显偏差无关，但目前的数据表明，患有SP-NAP的女性受试者骨骼生长轨迹发生了改变。
