de Barros L F, Gutierrez P S
Instituto do Coração do Hospital das Clínicas-FMUSP.
Arq Bras Cardiol. 1991 Nov;57(5):375-9.
To assess the hemodynamic and pathologic effects of the right coronary artery occlusion in anesthetized dogs submitted to pericardiotomy.
Ten mongrel dogs were anesthetized with pentobarbital and submitted to a right thoracotomy, pericardiotomy and ligation of the right coronary artery. The pericardium was kept opened throughout the entire experiment. The circulatory pressures and the cardiac output were determined twice before and three times after the right coronary artery ligation. The hearts were then excised, barium was injected in the coronary arteries and radiographs were taken to confirm the artery occlusion. Three dogs were kept alive to later pathologic examination of the hearts.
The observation of the radiographs showed proximal occlusion of the right coronary artery and absence of the right ventricle free wall vascularization. There was ischemic necrosis of about three quarters of this area, whereas the septum was normal. The cardiac index and the systemic mean arterial decreased 14% without significant variation of the central venous and the pulmonary artery pressures, although marked right ventricular dilation was observed.
The proximal right coronary artery ligation in the dog determines ischemia and infarction of the right ventricular free wall, without affecting the interventricular septum. There are few hemodynamic consequences with open pericardium and at rest.
评估在接受心包切开术的麻醉犬中右冠状动脉闭塞的血流动力学和病理影响。
十只杂种犬用戊巴比妥麻醉，接受右胸切开术、心包切开术和右冠状动脉结扎。在整个实验过程中，心包保持开放。在右冠状动脉结扎前测定两次循环压力和心输出量，结扎后测定三次。然后切除心脏，向冠状动脉内注入钡剂并拍摄X线片以确认动脉闭塞。三只犬存活以备后期心脏病理检查。
X线片观察显示右冠状动脉近端闭塞，右心室游离壁无血管化。该区域约四分之三出现缺血性坏死，而室间隔正常。心脏指数和体循环平均动脉压下降14%，中心静脉压和肺动脉压无明显变化，尽管观察到明显的右心室扩张。
犬右冠状动脉近端结扎可导致右心室游离壁缺血和梗死，而不影响室间隔。心包开放且处于静息状态时，血流动力学影响较小。
