Brydon Lena, Harrison Neil A, Walker Cicely, Steptoe Andrew, Critchley Hugo D
Department of Epidemiology and Public Health, Institute of Neurology at University College London, London, United Kingdom.
Biol Psychiatry. 2008 Jun 1;63(11):1022-9. doi: 10.1016/j.biopsych.2007.12.007. Epub 2008 Feb 1.
Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain.
We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design.
Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra.
Our findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
全身性感染通常会引发包括精神运动迟缓在内的疾病症状。先天性免疫反应过程中释放的炎性细胞因子与外周炎症信号向大脑的传递有关。
我们采用双盲、随机、交叉对照设计，运用功能性磁共振脑成像（fMRI）对16名健康男性接种伤寒疫苗后外周炎症的神经效应进行了研究。
疫苗接种对神经血管耦合没有整体影响，但在低水平视觉刺激期间显著扰乱了黑质内的神经反应性。在一项认知任务中，接种伤寒疫苗后循环白细胞介素-6水平较高的个体反应时间明显更慢。反应时间延长和白细胞介素-6反应增强与黑质内诱发的神经活动有关。
我们的研究结果为炎症与神经认知表现之间的相互作用提供了机制性见解，具体表明循环细胞因子和中脑多巴胺能核在介导全身性感染的精神运动后果中发挥作用。
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